Pacijente treba pažljivo pratiti u cilju prepoznavanja znakova i simptoma respiratorne depresije i sedacije. U ovom pogledu se preporučuje informisanje pacijenata i njihovih staratelja (kada je to primenljivo) o značajnosti prepoznavanja ovih simptoma (videti odeljak 4.five).
Predloženi mehanizam interakcije je kompetitivno vezivanje teofilina za adenozinske receptore u mozgu. Na taj način onemogućava se farmakodinamsko dejstvo diazepama, dolazi do npr. smanjenja sedativnog i psihomotornog dejstva diazepama.
Tramadol is often a nontraditional centrally performing analgesic using a twin system of action. It is just a weak opioid as well as a reuptake inhibitor for serotonin and norepinephrine.
Ukoliko se diazepam uzima istovremeno sa drugim lekovima sa centralnim dejstvom neophodno je imati u vidu farmakološka svojstva lekova koji se primenjuju; poseban oprez je neophodan ako su u pitanju supstance koje mogu pojačati dejstvo ili biti pojačane dejstvom diazepama kao što su neuroleptici, anksiolitici/sedativi, hipnotici, antidepresivi, antikonvulzivi, sedativni antihistaminici, antipsihotici, anestetici za opštu anesteziju i narkotički analgetici.
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Usled naglog prekida click here terapije benzodiazepinima kod pacijenata sa epilepsijom i drugih pacijenata koji u anamnezi imaju epileptične napade može doći do pojave konvulzija ili epileptičnog statusa.
If you're thinking that you or someone else can have taken an overdose of the medicine, get emergency aid at the same time. Your health care provider can also give naloxone along with other medicines to treat an overdose.
Applying narcotics for a long time could cause extreme constipation. To prevent this, your health practitioner may possibly direct you to definitely take laxatives, drink a lot of fluids, or raise the quantity of fiber as part of your eating plan.
Pharma common features Bensedin in tablet form that needs to be taken by mouth. You may take this one to 2 situations each day according to your healthcare ailment or as per the recommendation from the health practitioner.
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Ne smete koristiti lek Bensedin posle isteka roka upotrebe naznačenog na spoljašnjem pakovanju nakon „Važi do“. Datum isteka roka upotrebe se odnosi na poslednji dan navedenog meseca.
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Acquire diazepam as directed by your medical professional or healthcare Qualified. Begin to see the drug manuals very carefully and follow the instructions to the label. Your medical doctor can increase or lower your dose every so often, with regards to the professional medical situation.
Usled inhibicije CYP3A4 i/ili CYP2C19 metaboličkih puteva, povećana je koncentracija benzodiazepina u plazmi.